Ubiquitin

Cancer research

Biology

Gene

Cell biology

Cancer

Tumor progression

Ubiquitin ligase

Metastasis

Deubiquitinating enzyme

Genetics

International Journal of Biological Sciences

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival.Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis.This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis.Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

The role of ubiquitination and deubiquitination in tumor invasion and metastasis