Internal medicine

Immunoglobulin E

Pathology

Biotechnology

Antibody

Receptor

Immunology

Immunohistochemistry

In vivo

Ex vivo

Human skin

Mast cell

Pathogenesis

Tryptase

Degranulation

Genetics

Medicine

Biology

Journal of Allergy and Clinical Immunology

Chronic prurigo (CPG) is characterized by intensive itch and interactions among nerves, neuropeptides, and mast cells (MCs). The role of some neuropeptides such as cortistatin (CST) and its receptor, Mas-related G protein–coupled receptor X2 (MRGPRX2), in CPG remains poorly investigated.

Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo