Internal medicine

Nanotechnology

Nanocarriers

Biology

Cancer

Biophysics

Nanoparticle

Chemistry

Materials science

Extracellular

Cancer chemotherapy

Drug delivery

Drug

Cancer therapy

Biochemistry

Medicine

Intracellular

Magnetic nanoparticles

Pharmacology

Polymers

A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.

pH-Responsive Nanocarriers in Cancer Therapy