Internal medicine

Chromosomal translocation

Pediatrics

Maintenance therapy

Methotrexate

Population

Lymphoblastic Leukemia

Gastroenterology

Gene

Surgery

Oncology

Chemistry

Induction chemotherapy

Cyclophosphamide

Mercaptopurine

Blinatumomab

Chemotherapy

Leukemia

Philadelphia chromosome

Vincristine

Acute lymphocytic leukemia

Biochemistry

Medicine

Environmental health

Journal of Clinical Oncology

Chemotherapy outcomes in older patients with Philadelphia (Ph) chromosome-negative B-acute lymphoblastic leukemia (ALL) are very poor. Here, we evaluated blinatumomab as induction and consolidation therapy followed by prednisone, vincristine, 6-mercaptopurine, and methotrexate (POMP) maintenance chemotherapy in this patient population.

SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome–Negative B-Cell Acute Lymphoblastic Leukemia