Enhancer

Epigenetics

Philosophy

BRD4

Cancer research

Bromodomain

Psychological repression

Biology

Gene

Transcription (linguistics)

Cancer

Gene expression

Linguistics

Breast cancer

Internal medicine

Transcription factor

Genetics

Medicine

Proceedings of the National Academy of Sciences

Significance We found that BRD4 interacts with the LSD1/NuRD complex and colocalizes with this repressive complex on super-enhancers and that decommissioning BRD4-directed super-enhancer organization of transcription repression programs inflicts widespread drug resistance in breast cancer. The study uncovers a functional duality of BRD4 in super-enhancer organization of transcription activation and repression linking to oncogenesis and chemoresistance, respectively, supporting the pursuit of a combined targeting of BRD4 and PELI1 in effective treatment of breast cancer.

BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer