Quantum entanglement

Physics

Plasmid

Biology

Gene

Genome

Multipartite

Replicon

Transformation (genetics)

Agrobacterium tumefaciens

Circular bacterial chromosome

Quantum mechanics

Computational biology

Chromosome

Genetics

Quantum

Proceedings of the National Academy of Sciences

Significance How bacteria with multipartite genomes organize and segregate their DNA is poorly understood. Here, we investigate a prototypical multipartite genome in the plant pathogen Agrobacterium tumefaciens . We identify previously unappreciated interreplicon interactions: the four replicons cluster through interactions at their centromeres, and the two chromosomes, one circular and one linear, interact along their replication arms. Our data suggest that these interreplicon contacts play critical roles in the organization and maintenance of multipartite genomes.

Conformation and dynamic interactions of the multipartite genome in <i>Agrobacterium tumefaciens</i>

Conformation and dynamic interactions of the multipartite genome in Agrobacterium tumefaciens