Protein sequencing

Gene

Signal peptide

Metagenomics

Secretory protein

Peptide sequence

Programming language

Sequence (biology)

SIGNAL (programming language)

Computer science

Secretion

Amino acid

Biochemistry

Computational biology

Biology

Nature Biotechnology

Signal peptides (SPs) are short amino acid sequences that control protein secretion and translocation in all living organisms. SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs. We introduce SignalP 6.0, a machine learning model that detects all five SP types and is applicable to metagenomic data.

SignalP 6.0 predicts all five types of signal peptides using protein language models