Ryanodine receptor

Algorithm

Hibernation (computing)

Internal medicine

Endocrinology

Thermogenesis

Endoplasmic reticulum

Adipose tissue

Chemistry

RYR1

Adenosine

Adenosine triphosphate

Skeletal muscle

Dantrolene

Computer science

State (computer science)

Calcium

Biochemistry

Medicine

Basal metabolic rate

Biology

Cell biology

Proceedings of the National Academy of Sciences

Significance The evolution of mammals to use skeletal muscle as a source of heat allowed them to spread to all parts of the globe. The generation of heat requires increased adenosine triphosphate (ATP) hydrolysis in the resting muscle in a regulated manner, but how this mechanism works is unknown. The results suggest that mammals increase their RyR1 Ca 2+ leak rate to amplify a basal ATP turnover rate at the sarcoplasmic reticulum Ca 2+ pump that is higher than that of lower vertebrates. Muscle-based thermogenesis allows regulation of body temperature that is essential for life in mammals and provides a potential pathway for manipulating body weight or temperature by altering metabolic rate.

Ca <sup>2+</sup> leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

Ca 2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

Ca ²⁺ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle