Physics

RNA world hypothesis

Nanotechnology

Key (lock)

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Gene

Component (thermodynamics)

Chemistry

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Materials science

Ribozyme

Biochemistry

Thermodynamics

Nature Communications

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.

An ionizable lipid toolbox for RNA delivery