Antibody Drug Conjugates: Nonclinical Safety Considerations
Abstract
Antibody drug conjugates (ADCs) are biopharmaceutical molecules consisting of a cytotoxic small molecule covalently linked to a targeted protein carrier via a stable cleavable or noncleavable linker. The process of conjugation yields a highly complex molecule with biochemical properties that are distinct from those of the unconjugated components. The impact of these biochemical differences on the safety and pharmacokinetic (PK) profile of the...
Paper Details
Title
Antibody Drug Conjugates: Nonclinical Safety Considerations
Published Date
May 30, 2015
Journal
Volume
17
Issue
5
Pages
1055 - 1064
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