Glycomics

Glycoprotein

Function (biology)

Pathology

Galectin

Glycome

Glycan

Glycosylation

Disease

N-linked glycosylation

Biochemistry

Computational biology

Medicine

Biology

Cell biology

European Journal of Cell Biology

N-linked glycosylation is a post-translational modification crucial for membrane protein folding, stability and other cellular functions. Alteration of membrane protein N-glycans is implicated in wide range of pathological conditions including cancer metastasis, chronic inflammatory diseases, and viral pathogenesis. Even though the roles of N-glycans have been studied extensively, our knowledge of their mechanisms remains unclear due to the lack of detailed structural analysis of the N-glycome. Mapping the N-glycome landscape will open new avenues to explore disease mechanisms and identify novel therapeutic targets. This review discusses the diverse structure of N-linked glycans, the function and regulation of N-glycosylation in health and disease, and ends with a focus on recent approaches to target N-glycans in rheumatoid arthritis and cancer metastasis.

Advances in understanding N-glycosylation structure, function, and regulation in health and disease