Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity

Volume: 12, Issue: 12, Pages: 1942 - 1947
Published: Nov 23, 2021
Abstract
Hit-to-lead studies employ a variety of strategies to optimize binding to a target of interest. When a structure for the target is available, hypothesis-driven structure-activity relationships (SAR) are a powerful strategy for refining the pharmacophore to achieve robust binding and selectivity characteristics necessary to identify a lead compound. Recrafting the three-dimensional space occupied by a small molecule, optimization of hydrogen bond...
Paper Details
Title
Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity
Published Date
Nov 23, 2021
Volume
12
Issue
12
Pages
1942 - 1947
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