Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

Volume: 219, Issue: 1
Published: Dec 2, 2021
Abstract
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology and altered phenotypes of plaque-associated microglia. Here, we show that a short, 7-d treatment of preweaned male mice with high-dose ABX is associated with reductions of Aβ amyloidosis, plaque-localized microglia morphologies, and Aβ-associated degenerative changes at 9 wk of...
Paper Details
Title
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
Published Date
Dec 2, 2021
Volume
219
Issue
1
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