Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex
Abstract
The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that shape maintenance and function of anti-viral T cell immunity in the body by comprehensive profiling of virus-specific T cells across blood, lymphoid organs, and mucosal tissues of organ donors. We use flow cytometry, T cell receptor sequencing, single-cell transcriptomics, and cytokine...
Paper Details
Title
Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex
Published Date
Nov 1, 2021
Journal
Volume
37
Issue
9
Pages
110071 - 110071
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Notes
History