Psychology

Chemistry

Inflammation

Blood–brain barrier

Biochemistry

Physics

Central nervous system

Neuroinflammation

Neuroscience

Membrane

Term (time)

Endocrinology

Quantum mechanics

Hippocampus

Brain function

Hippocampal formation

Permeability (electromagnetism)

Internal medicine

Medicine

Frontiers in Neuroscience

Graphical Abstract An illustrative scheme summarizing the main outcomes in Swiss mice fed high-fat diet (HFD), with their exact time of onset of changes in the hippocampus. An increase in the expression of proinflammatory cytokines, together with the permeability of the blood–brain barrier was detected after 2 days of HFD. Even in the first week of dietary intervention, memory and learning impairment, depressive-like behavior, and synaptic changes were observed at 3, 5, and 7 days, respectively. Later hippocampal alterations (after 4 weeks of HFD consumption) include mitochondrial dysfunction and astrocytic activation.

Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood–Brain Barrier Permeability and Neuroinflammation as Triggering Events