A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B

The ribosome-targeted antifungal agent hygromycin B (HygB) alters the secondary metabolite profiles of fungi. Hypoxylon truncatum NBRC 32353 fermented in the presence of hygromycin B in barley medium activated secondary metabolite synthesis. A new benzaldehyde derivative truncaaldehyde (1) was obtained, along with thirteen known compounds (2–14). The structures of the new compounds were revealed using NMR and single-crystal X-ray...