Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages
Abstract
The anaphylatoxin C5a is core effector of complement activation. C5a exerts potent proinflammatory and immunomodulatory actions through interacting with its C5a receptors, C5aR1 and C5aR2, modulating multiple signaling and functional activities of immune cells. Native C5a contains a large N-linked glycosylation site at Asn64, which accounts for up to 25% of its m.w. To date, the vast majority of published studies examining C5a are performed...
Paper Details
Title
Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages
Published Date
Jan 1, 2022
Journal
Volume
208
Issue
1
Pages
133 - 142
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Notes
History