Aquaporin 9 induction in human i PSC ‐derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency
Abstract
Patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps) have facilitated the study of rare genetic liver diseases. Here, we aimed to establish an in vitro liver disease model of the urea cycle disorder ornithine transcarbamylase deficiency (OTCD) using patient-derived hiPSC-Heps.Before modeling OTCD, we addressed the question of why hiPSC-Heps generally secrete less urea than adult primary human...
Paper Details
Title
Aquaporin 9 induction in human i PSC ‐derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency
Published Date
Dec 18, 2021
Journal
Volume
76
Issue
3
Pages
646 - 659
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