BRAF-Inhibitor-Induced Metabolic Alterations in A375 Melanoma Cells
Abstract
Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug-tolerant mutants in cancer. Cells in this dynamic persister state can escape drug treatment by undergoing various epigenetic changes, which may result in a transient metabolic rewiring. In this study, with the use of untargeted metabolomics and...
Paper Details
Title
BRAF-Inhibitor-Induced Metabolic Alterations in A375 Melanoma Cells
Published Date
Nov 14, 2021
Journal
Volume
11
Issue
11
Pages
777 - 777
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