Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave
Abstract
Programmed death-ligand 1 (PD-L1) is one of the most classic immune checkpoint molecules. Cancer cells express PD-L1 to inhibit the activity of effector T cells’ cytotoxicity through programmed death 1 (PD-1) engagement in exposure to inflammatory cytokines. PD-L1 expression levels on cancer cells might affect the clinical response to anti-PD-1/PD-L1 therapies. Hence, understanding molecular mechanisms for regulating PD-L1 expression is...
Paper Details
Title
Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave
Published Date
Nov 16, 2021
Journal
Volume
9
Issue
11
Pages
1702 - 1702
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Notes
History