Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c
Abstract
Although gene expression is tightly regulated during embryonic development, the impact of translational control has received less experimental attention. Here, we find that eukaryotic translation initiation factor-3 (eIF3) is required for Shh-mediated tissue patterning. Analysis of loss-of-function eIF3 subunit c (Eif3c) mice reveal a unique sensitivity to the Shh receptor patched 1 (Ptch1) dosage. Genome-wide in vivo enhanced cross-linking...
Paper Details
Title
Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c
Published Date
Nov 1, 2021
Journal
Volume
56
Issue
21
Pages
2928 - 2937.e9
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