Aza-heterocycles via copper-catalyzed, remote C–H desaturation of amines

Chem23.50
Volume: 8, Issue: 1, Pages: 210 - 224
Published: Jan 1, 2022
Abstract
The majority of medicines contain a nitrogen atom within a five- or six- membered ring. To rapidly access both such aza-heterocycles, we sought to develop a remote C-H desaturation of amines. Inspired by the Hofmann-Löffler-Freytag synthesis of five-membered pyrrolidines, we tackled the century-old challenge of synthesizing six-membered piperidines by H-atom transfer. We present herein a double, vicinal C-H oxidation by dual catalysis, entailing...
Paper Details
Title
Aza-heterocycles via copper-catalyzed, remote C–H desaturation of amines
Published Date
Jan 1, 2022
Journal
Volume
8
Issue
1
Pages
210 - 224
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