Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane
Abstract
Ornithine decarboxylase (ODC) is the rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are oncometabolites that are required for proliferation, and pharmaceutical ODC inhibition is pursued for the treatment of hyperproliferative diseases, including cancer and infectious diseases. The most potent ODC inhibitor is 1-amino-oxy-3-aminopropane (APA). A previous crystal structure of an ODC–APA complex indicated that APA non-covalently...
Paper Details
Title
Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane
Published Date
Nov 19, 2021
Journal
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