Rare mutation in MKRN3 in two twin sisters with central precocious puberty: Two case reports

Volume: 9, Issue: 32, Pages: 10018 - 10023
Published: Nov 16, 2021
Abstract
Caused by premature activation of the hypothalamic-pituitary-gonadal axis, there is increasing incidence of central precocious puberty (CPP), especially in girls. Makorin ring finger protein 3 (MKRN3), a maternal imprinted gene with a highly conserved sequence, is the most common genetic etiology associated with CPP. Approximately 50 different mutations in MKRN3 have been found in CPP.This case report involves identical twin sisters presenting...
Paper Details
Title
Rare mutation in MKRN3 in two twin sisters with central precocious puberty: Two case reports
Published Date
Nov 16, 2021
Volume
9
Issue
32
Pages
10018 - 10023
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