TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Abstract
Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes and allows cell-cell and cell-environment communication. Dysregulation of TMEMs has been observed in multiple cancers. However, little is known about TMEM116 in cancer development. In this study, we demonstrate that TMEM116 is highly expressed in non-small-cell lung cancer (NSCLC) tissues and cell lines. Inactivation of TMEM116 reduced cell proliferation,...
Paper Details
Title
TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Published Date
Nov 16, 2021
Journal
Volume
12
Issue
12
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