The most immature infants: Is evidence-based practice possible?

At extremely low gestational ages, preterm infants are markedly physiologically immature, thus their responses to common clinical interventions may differ from more mature preterm babies. This study was performed to describe the evidence base which is available to make care decisions for such infants.A literature search of recent large neonatal randomized controlled trials (RCTs) was performed to determine the representation of infants <25 weeks...