Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein
Volume: 118, Issue: 48
Published: Nov 15, 2021
Abstract
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates membrane fusion to allow entry of the viral genome into host cells. To understand its detailed entry mechanism and develop a specific entry inhibitor, in situ structural information on the SARS-CoV-2 spike protein in different states is urgent. Here, by using cryo-electron tomography, we observed both prefusion and postfusion spikes in...
Paper Details
Title
Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein
Published Date
Nov 15, 2021
Volume
118
Issue
48
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