Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies
Abstract
Repeat antigens, such as the Plasmodium falciparum circumsporozoite protein (PfCSP), use both sequence degeneracy and structural diversity to evade the immune response. A few PfCSP-directed antibodies have been identified that are effective at preventing malaria infection, including CIS43, but how these repeat-targeting antibodies might be improved has been unclear. Here, we engineered a humanized mouse model in which B cells expressed inferred...
Paper Details
Title
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies
Published Date
Dec 1, 2021
Journal
Volume
54
Issue
12
Pages
2859 - 2876.e7
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