Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase

Volume: 100, Issue: 6, Pages: 1158 - 1160
Published: Dec 1, 2021
Abstract
Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition in renal tubular epithelial cells. Because several other protein kinase inhibitors are also known to cause ferrochelatase inhibition, further...
Paper Details
Title
Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase
Published Date
Dec 1, 2021
Volume
100
Issue
6
Pages
1158 - 1160
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