PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa

Volume: 2021, Pages: 1 - 10
Published: Nov 11, 2021
Abstract
Retinitis pigmentosa (RP) is a major cause of blindness that is difficult to diagnose and treat. PKM2, a subtype of pyruvate kinase, is strongly associated with oxidative stress and is expressed in photoreceptors. We investigated whether PKM2 reduces photoreceptor cell apoptosis and evaluated possible antiapoptotic mechanisms in RP. We established RP models by exposing 661W cells to blue light and modulated PKM2 activity using a PKM2 inhibitor....
Paper Details
Title
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa
Published Date
Nov 11, 2021
Volume
2021
Pages
1 - 10
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