Discontinuation of disease modifying therapies is associated with disability progression regardless of prior stable disease and age

Multiple sclerosis (MS) patients with stable disease course might view continued treatment as unnecessary. However, guidelines regarding treatment discontinuation are currently lacking.To assess the clinical course after treatment discontinuation in MS patients with long disease duration.Patients who discontinued disease-modifying treatments (DMTs) and not resume treatment (n = 216) were extracted from New York State MS Consortium (NYSMSC) and...