Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms

Introduction A potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice are complicated by non-selective deletion of Gpr21 . Research design and methods We hypothesized that a Gpr21 -selective knockout mouse model, coupled with type 2 diabetes patient samples, would clarify these issues and enable...