Fasting augments pyrrolizidine alkaloid-induced hepatotoxicity
Abstract
Pyrrolizidine alkaloids (PAs) are phytotoxins widely present in various natural products and foodstuffs. The present study aims to investigate the effects of fasting on PA-induced hepatotoxicity and the underlying biochemical mechanisms. The results of hepatotoxic study showed that 15-h overnight fasting significantly exacerbated the hepatotoxicity of retrorsine (RTS, a representative toxic PA) in fasted rats compared to fed rats, as indicated...
Paper Details
Title
Fasting augments pyrrolizidine alkaloid-induced hepatotoxicity
Published Date
Nov 18, 2021
Journal
Volume
96
Issue
2
Pages
639 - 651
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