DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions
Volume: 66, Issue: 24, Pages: 245017 - 245017
Published: Dec 15, 2021
Abstract
The chemical stage of the Monte Carlo track-structure (MCTS) code Geant4-DNA was extended for its use in DNA strand break (SB) simulations and compared against published experimental data. Geant4-DNA simulations were performed using pUC19 plasmids (2686 base pairs) in a buffered solution of DMSO irradiated by60Co or137Csγ-rays. A comprehensive evaluation of SSB yields was performed considering DMSO, DNA concentration, dose and plasmid...
Paper Details
Title
DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions
Published Date
Dec 15, 2021
Volume
66
Issue
24
Pages
245017 - 245017
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