Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production
Abstract
OTULIN is a linear deubiquitinase that negatively regulates the nuclear factor κB (NF-κB) signaling pathway. Patients with OTULIN deficiency, termed as otulipenia or OTULIN-related autoinflammatory syndrome, present with early onset severe systemic inflammation due to increased NF-κB activation. We aimed to investigate additional disease mechanisms of OTULIN deficiency. Our study found a remarkable activation of type I interferon (IFN-I)...
Paper Details
Title
Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production
Published Date
Nov 19, 2021
Journal
Volume
7
Issue
47
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