Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Abstract
Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered...
Paper Details
Title
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Published Date
Nov 15, 2021
Journal
Volume
28
Issue
1
Pages
201 - 211
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