Mutagenesis of the l-Amino Acid Ligase RizA Increased the Production of Bioactive Dipeptides
Abstract
The l-amino acid ligase RizA from B. subtilis selectively synthesizes dipeptides containing an N-terminal arginine. Many arginyl dipeptides have salt-taste enhancing properties while Arg-Phe has been found to have an antihypertensive effect. A total of 21 RizA variants were created by site-directed mutagenesis of eight amino acids in the substrate binding pocket. The variants were recombinantly produced in E. coli and purified by affinity...
Paper Details
Title
Mutagenesis of the l-Amino Acid Ligase RizA Increased the Production of Bioactive Dipeptides
Published Date
Nov 17, 2021
Journal
Volume
11
Issue
11
Pages
1385 - 1385
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Notes
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