Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol

Volume: 45, Issue: 1, Pages: 232 - 240
Published: Nov 17, 2021
Abstract
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We conducted summary-level univariable and multivariable Mendelian randomization (MR) analyses in 921,908 participants to investigate the effect of lowering LDLc on type 2 diabetes risk and the proportion...
Paper Details
Title
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
Published Date
Nov 17, 2021
Volume
45
Issue
1
Pages
232 - 240
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