R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

Volume: 7, Issue: 47
Published: Nov 19, 2021
Abstract
How DNA damage leads to chronic inflammation and tissue degeneration with aging remains to be fully resolved. Here, we show that DNA damage leads to cellular senescence, fibrosis, loss-of-tissue architecture, and chronic pancreatitis in mice with an inborn defect in the excision repair cross complementation group 1 (Ercc1) gene. We find that DNA damage-driven R-loops causally contribute to the active release and buildup of single-stranded DNAs...
Paper Details
Title
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage
Published Date
Nov 19, 2021
Volume
7
Issue
47
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