HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases
Abstract
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of various diseases, especially autoimmune diseases. Fine-mapping of causal variants in this region was challenging due to the difficulty in sequencing and its inapplicability to large cohorts. Thus, HLA imputation, a method to infer HLA types from regional single nucleotide polymorphisms, has been developed and...
Paper Details
Title
HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases
Published Date
Nov 16, 2021
Journal
Volume
44
Issue
1
Pages
15 - 28
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