IFNγ Signaling in Natural and Therapy-Induced Antitumor Responses
Abstract
IFNγ is a cytokine produced by a restricted number of immune cells that acts on every nucleated cell type. Consistent with this remarkably wide spectrum of targets, the effects of IFNγ are highly pleiotropic. On cells of the immune system, IFNγ signaling has generally a pro-inflammatory effect, coordinating the innate and adaptive responses. On nonimmune cells, IFNγ tends to exert the opposite effect; it inhibits cell proliferation, induces cell...
Paper Details
Title
IFNγ Signaling in Natural and Therapy-Induced Antitumor Responses
Published Date
Nov 16, 2021
Journal
Volume
28
Issue
7
Pages
1243 - 1249
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