Native mass spectrometry-based metabolomics identifies metal-binding compounds
Abstract
Although metals are essential for the molecular machineries of life, systematic methods for discovering metal-small molecule complexes from biological samples are limited. Here, we describe a two-step native electrospray ionization-mass spectrometry method, in which post-column pH adjustment and metal infusion are combined with ion identity molecular networking, a rule-based data analysis workflow. This method enabled the identification of...
Paper Details
Title
Native mass spectrometry-based metabolomics identifies metal-binding compounds
Published Date
Nov 18, 2021
Journal
Volume
14
Issue
1
Pages
100 - 109
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