An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Published: Nov 15, 2021
Abstract
The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ quantitative proteomic profiling to identify proteins whose expression is regulated by the ERK5 pathway in mESCs. This reveals a function for ERK5 signalling in regulating dynamically expressed early embryonic 2-cell...
Paper Details
Title
An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells
Published Date
Nov 15, 2021
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