GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation
Abstract
Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D2 receptor DP1 signaling mechanism during infancy to recruit newborn astrocytes that ‘escort’ them into adulthood, and that the impairment of...
Paper Details
Title
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation
Published Date
Nov 18, 2021
Journal
Volume
24
Issue
12
Pages
1660 - 1672
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