A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations

Volume: 12, Issue: 11, Pages: e00427 - e00427
Published: Nov 1, 2021
Abstract
Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder.We investigated the effect of SSP2518 on GCC-mediated intracellular cyclic guanosine monophosphate (cGMP) levels and on GCC-mediated chloride secretion in intestinal organoids from 3 patients with distinct activating GCC mutations and from controls,...
Paper Details
Title
A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations
Published Date
Nov 1, 2021
Journal
Volume
12
Issue
11
Pages
e00427 - e00427
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