Optimization of ultrasound-assisted extraction of bioactive compounds from Achillea kellalensis using response surface methodology

The present paper aims to optimize the extraction conditions of Achillea kellalensis Boiss. & Hausskn., endemic to Iran, with assistance of sonication to exploit the potential health benefits of its extract. The Box-Behnken experimental design was employed to investigate the influence of the sonication amplitude (50–100%), extraction time (10–30 min), ethanol concentration (30–70%), and solvent-to-solid ratio (20:1–40:1) on responses of...