4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of β-anomer of 4'-thionucleoside and its Biological Activities

Volume: 29, Issue: 21, Pages: 3684 - 3731
Published: Jun 1, 2022
Abstract
The first highly diastereoselective synthesis of β-anomers of 4’-thionucleosides has been carried out by means of electrophilic glycosidation utilizing 3,5-O-(di-t-butylsilylene) (DTBS)-4-thiofuranoid glycal as a glycosyl donor. The resulting glycosides were transformed into ribo-, 2’-deoxy- and arabinofuranosyl nucleosides through a chemical transformation of the 2’-substituent. The additive Pummerer reaction of the glycal S-oxide gave...
Paper Details
Title
4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of β-anomer of 4'-thionucleoside and its Biological Activities
Published Date
Jun 1, 2022
Volume
29
Issue
21
Pages
3684 - 3731
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