Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition
Abstract
Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and consequently enhances guanylyl cyclase-A (GC-A/NPR1) signaling. However, the roles of OSTN in the kidney have not been well clarified. Adriamycin (ADR) nephropathy in wild-type mice showed albuminuria,...
Paper Details
Title
Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition
Published Date
Nov 8, 2021
Journal
Volume
11
Issue
1
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