Tumor innervation is triggered by endoplasmic reticulum stress
Abstract
Nerve infiltration in the tumor microenvironment is emerging as a promoter of cancer progression that could be targeted in therapies, but the mechanisms initiating tumor innervation remain to be elucidated. Here we report that endoplasmic reticulum (ER) stress in cancer cells is transmitted to neuronal cells, resulting in neurite outgrowth and tumor innervation. In vitro, the induction of ER stress in various human cancer cells resulted in the...
Paper Details
Title
Tumor innervation is triggered by endoplasmic reticulum stress
Published Date
Nov 16, 2021
Journal
Volume
41
Issue
4
Pages
586 - 599
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History