Cancer immunotherapy trial design with random delayed treatment effect and cure rate
Abstract
Immunotherapies are increasingly used for treating patients with advanced‐stage cancers. However, cancer immunotherapy trials often present delayed treatment effects and long‐term survivors which result nonproportional hazard models and challenge the immunotherapy trial designs. In this article, we proposed a general random delayed cure rate model for designing cancer immunotherapy trials. A sample size formula is derived for a weighted log‐rank...
Paper Details
Title
Cancer immunotherapy trial design with random delayed treatment effect and cure rate
Published Date
Nov 15, 2021
Journal
Volume
41
Issue
4
Pages
786 - 797
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Notes
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